Endocrine Abstracts

Hyperphosphatemic familial tumoral calcinosis (HFTC) is a condition characterized by an increase in the levels of phosphate in the blood (hyperphosphatemia) and abnormal deposits of phosphate and calcium (calcinosis) in in the soft tissue in the periarticular location outside the joint capsule.Case report: This girl presented at the age of 10 years with swelling and pain in the right hip region. On examination a 10×10 cm hard, non-tender swelling wi...

Objective: To evaluate semen parameters and measure serum FSH, LH, Testosterone (T) concentrations before and 6 weeks after i.v. (800–1200 mg elemental iron iron therapy in adults with iron deficiency anemia.Patients and methods: This study investigated 11 adults with iron deficiency anemia (IDA) aged 40±5 years, with full pubertal development (Tanner stage 5, eugonadal) and capacity to ejaculate. They had iron deficiency anemia mainly due to d...

Profound hypothyroidism leading to coma has not been reported in adolescents.Case presentation: A 13-year-old adolescent girl presented with coma. Mother reported fatigue, increased sleepiness, deterioration of school performance, apathy, secondary amenorrhea, change in voice, and weight gain for 5 months. No history of dyspnea, palpitations or chest pain, drug intake, trauma, or any systemic illness. No family history of endocrine disorders was reported...

Introduction: The uncertainty surrounding the optimal dose to rectify severe vitamin D deficiency (VDD) necessitates further investigation.Aim: To review and analyze various vitamin D (VD) supplementation doses, durations, and their effects on 25-hydroxyvitamin D (25OHD) levels, along with their biochemical and clinical outcomes, in the management of VDD.Methods: We reviewed intervention studies targeting VDD from databases (PubMed...

Introduction: The relationship between early puberty and abnormal bone health has garnered significant research attention, with varying outcomes. Objectives: This review systematically examines studies up to March 2023 to determine whether early puberty is associated with abnormal bone health, specifically low bone mineral density (BMD), osteopenia, and osteoporosis. We analyze and summarize research articles (n=25) to elucidate the potential li...

We conducted a longitudinal study on 95 children presented to pediatric clinic with short stature. Children were classified to low IGF1 (IGF1SDS <-1) (n=25) and normal IGF1 (IGF1SDS >-1) (n=70) and treated with human GH (0.03: 0.05 mg/kg/day) for 2 years. Anthropometrics data (HtSDS, difference from mid-parental height SDS (MPHSD), BMISDS, bone age and IGF1 level were studied for 2 years.Results: At presentation, the age, bone a...

The Relationship between Precocious/Early Puberty and Obesity with Metabolic Abnormalities: A Comprehensive ReviewIntroduction: The impact of pubertal timing on the development of obesity and metabolic abnormalities has been the subject of extensive research with variable outcomes. Objective: We systematically reviewed studies (Medline, Pubmed, Google scholar, and Web of Science) 2000 until March 2023 evaluating the relation betwee...

This study aimed to explore the prevalence of distinct Metabolic Syndrome (MetS) components and plasma AIP among obese children and adolescents, and to evaluate their anthropometric measures in comparison to their parents, thereby considering genetic and environmental influences.Methodology: Anthropometric and biochemical profiles of 91 randomly selected obese children and young adolescents (mean age: 10.5&pm;2.7 years) were meticulously analyzed. This c...

Introduction: The contribution of reproductive factors to breast cancer (BC) susceptibility requires further investigation. This study aims to explore the potential link between early puberty (menarche) and the risk of breast cancer in women.Aim: This study systematically reviews research conducted between 2000 and March 2023, aiming to evaluate the association between early/precocious puberty and the incidence of BC.Methods: A com...

Background: Pituitary microadenomas in pediatric populations, though infrequent, present diagnostic and therapeutic challenges.Methods: We retrospectively reviewed six pediatric cases of pituitary microadenomas diagnosed and treated at our institution. The cases were analyzed for presenting symptoms, hormonal profiles, and treatment responses.Results: Case 1: A 12-year-old with growth hormone deficiency showed significant height im...